The book opens with Vampire$, Inc. cleaning out a nest of vampires, introducing the main characters and setting the tone for the book. The team has some difficulty collecting their payment for dispatching said vampires, but ultimately collects their fee and hosts a wild party at a local motel where all of the team and some townsfolk engage in epic-level drinking and carrying on. The party is interrupted by a 'master' vampire who essentially slaughters everyone at the party with the exception of Jack Crow and his second in command "Cherry Cat" Catlin.
A shaken Jack Crow regroups and begins to plan the formation of a new team, aided by Father Adam, a knowledgeable young priest sent to him by the Vatican. Events at the motel slaughter lead Jack to realize that silver, particularly blessed silver from a cross, can be used as a weapon against vampires. He has his weaponsmith Carl begin creating silver bullets and he recruits a skilled gunman named Felix, that Jack met while working as a government agent in Mexico. Felix proves to be as deadly with a pistol as Jack hoped and they seem to have a new and powerful resource to use against the vampires. In addition to the silver bullets, Carl also develops a "vampire detector" for use by the team, which proves to be a useful tool against the vampires (which are portrayed as fantastically fast and powerful compared to humans, particularly the 'master vampires').
A series of battles ensues, using these silver bullets against the vampires, but key members of Jack's team are killed by the vampires, including a mother-figure Annabelle (who essentially "office managed" the team's residence and affairs) and the aging weaponsmith Carl. Jack, depressed and beaten, suicidally returns to a known favorite hotel where the vampires are sure to find him. Felix, Cat and Father Adam stage a rescue attempt but it ends with Father Adam dead and Jack spirited away by the vampire.
Français
Jack Crow et son équipe de Vampire$ Inc. sont mandatés par le Vatican dans un seul but : éradiquer les vampires. Un bien douloureux combat qu'ils ne gagneront jamais, et ils le savent fort bien. Car ces buveurs de sang existent bel et bien, bien que les médias nient leur existence, malgré les fictions stupides qui les décrivent bien mal. Les vampires sont une réalité a laquelle Jack Crow doit faire face comme il l'a toujours fait : seul, envers et contre tous.
Et quand le Maître du nid que Vampire$ Inc. vient de nettoyer se présente à la fête organisée le soir même et étripe tous les membres de l'équipe dans un massacre horrible, Jack Crow n'a pas d'autre choix que de fuir. Mais comment diable le Maître connait-il le nom de Jack Crow ? Qui devient le chasseur ? Qui devient la proie ?
The novel closes with Felix taking a leadership role within Vampire$ Inc., after thwarting an attempt by the (now a vampire) Jack Crow to attack the Pope.