While watching the news on cable, Buck (Robert Patrick) discovers that his old "butt buddy," Luther Hecks (Duane Whitaker), has escaped from prison, and Texas ranger Otis Lawson (Bo Hopkins) is hunting for him. Shortly after Otis pays Buck a visit, Buck gets a phone call from Luther. He wants Buck to put together the old gang and meet him at the El Coyote Motel in Mexico because of some big deal he's cooked up. Buck promptly sets to rounding up the guys—C.W. Niles (Muse Watson), Jesus (Raymond Cruz), and Ray Bob (Brett Harrelson) -- and they're on their way.
Also on his way in his car, Luther hits and kills a big bat. When the car won't start, Luther hoofs it over to a nearby bar, the Titty Twister (open dusk till dawn) where he is offered a ride to the El Coyote by the bartender (Razor Eddie). However, when Razor Eddie (Danny Trejo) finds out about the bat that Luther hit, he turns back. The bat is actually his friend Victor (Joe Virzi). Victor and Razor Eddie eventually subdue Luther and turn him into a vampire.
Meanwhile, at the El Coyote, Buck, Roy Bob, C.W., and Jesus are watching porno movies. Luther eventually makes it to the El Coyote where he attacks Jesus's lady-of-the-evening and makes her a vampire. She then turns Jesus. The five of them head off to Bravos to rob the Banco Bravos. Once inside the bank, Luther and Jesus bite the guard and start working on the other boys. First to go is C.W., followed by Ray Bob, leaving only Buck left human. When Otis and a huge SWAT team surround the bank, the blood bath really starts. Buck escapes and joins forces with Otis. Together they manage to kill off the vampires as well as the newly undead SWAT team.
Italiano
Cinque criminali decidono di fare una rapina, e si dirigono in Messico.Due dei cinque vengono vampirizzati,ma sotto mentite spoglie umane si riuniscono agli altri tre della banda per effettuare comunque la rapina.Nottetempo,entrati nella banca,i due vampiri,uno dopo l'altro, vampirizzano il resto della banda,tranne uno (il protagonista).Nello stesso tempo i 5 della banda combattono con la polizia che nel mentre si è radunata fuori dalla banca.