1885 Transylvania : Abraham Van Helsing [Rhett Giles] eaves his wife in the care of Monk Sebastien [Andreas Beckett] while he and his slayers penetrate the lair of Count Vladimir Dracula. Although Van Helsing successfully destroys Dracula, the cost is great. The monk Sebastien is actually a vampire prince, and while Van Helsing is out killing vampires, Sebastien turns Van Helsing's wife into one.
Present day Los Angeles: Dr Abraham Van Helsing, slayer of vampires, is laying low, working as a hematologist at University Hospital after just moving there from Paris. Vampires have been lying low, too, drinking the cold blood of dead animals, not hunting humans, basically starving themselves all on account of their fear of Van Helsing. Roman [Jared Cohn] can't take it anymore. He gets a job at University Hospital as an orderly and steals three pints of blood from the blood bank. When Arianna [Denise Boutte], chief vampire bitch, sees the name on the label -- Dr Abraham Van Helsing -- she begins to shiver in her black, high-heeled, lace-up boots and runs straight to Sebastien (after taking a few swigs of the blood herself). She offers the blood to Sebastien, who has disintegrated into a withered, sniffling, lustless ragtag lying on a couch and talking in word salad. Arianna forces a sip of the human blood down his throat and, after that one sip, Sebastien knows what he must do -- unite all the vampires, feed again on humans, show them who's boss, and kill Van Helsing. However, killing Van Helsing isn't going to be easy. After being forced to destroy his own wife, Van Helsing turned to the Knights Templar and made a deal with God. Until he kills the last vampire prince, Van Helsing will walk the earth as an immortal. The only stipulation is that, should he ever drink vampire blood, he will be turned and forever damned.