Following her conviction at the end of Vampire Zero for stepping outside the law and torturing a convict for critical information she used to destroy her former mentor-turned-vampire, vampire hunter Laura Caxton is imprisoned in a maximum security penitenary when it is invaded by Justinia Malvern, the world’s oldest vampire, intent on killing the former state police trooper. Malvern has used her vampiric skills to convert the prison's warden to her side, setting up the entire prison population to either accept her vampire's curse or become feeding stock for Malvern and her converts. Caxton must fight her way out of the prison and save her captured girlfriend as well.